Very Early-onset Inflammatory Bowel Disease
نویسندگان
چکیده
منابع مشابه
Late-onset inflammatory bowel disease in the very elderly.
Elderly-onset inflammatory bowel disease (IBD) will be seen more frequently with the ageing of the population and the increasing incidence of IBD. However, knowledge regarding the best approach to IBD in this population is scarce. Furthermore, differential diagnosis in elderly patients with diarrhoea, rectal blood loss or a changed defecation pattern is comprehensive and IBD is not always consi...
متن کاملDefects in NADPH Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease
BACKGROUND & AIMS Defects in intestinal innate defense systems predispose patients to inflammatory bowel disease (IBD). Reactive oxygen species (ROS) generated by nicotinamide-adenine dinucleotide phosphate (NADPH) oxidases in the mucosal barrier maintain gut homeostasis and defend against pathogenic attack. We hypothesized that molecular genetic defects in intestinal NADPH oxidases might be pr...
متن کاملMaintaining Intestinal Health: The Genetics and Immunology of Very Early Onset Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a multifactoral disease caused by dysregulated immune responses to commensal or pathogenic microbes in the intestine, resulting in chronic intestinal inflammation. An emerging population of patients with IBD occurring before the age of 5 represent a unique form of disease, termed Very Early Onset (VEO)-IBD, which is phenotypically- and genetically-distinct fr...
متن کاملIL-10 and IL-10 Receptor Mutations in Very Early Onset Inflammatory Bowel Disease
Very early onset inflammatory bowel disease (VEO-IBD) is a unique disease entity with a complex genetic susceptibility in affected patients. Next-generation gene sequencing techniques have revealed various monogenetic mutations contributing to the pathogenesis of VEO-IBD, including interleukin 10 (IL-10) and IL-10 receptor (IL-10R) mutations. In this article, we reviewed the features of and eff...
متن کاملEpithelial Reactive Oxygen Species and Risk for Very Early Onset Inflammatory Bowel Disease
Figure 1. The article by Hayes et al identifies novel mutations in two genes, NOX1 and DUOX2, in patients with very early onset IBD. Functional analyses suggest that these mutations disrupt production of reactive oxygen species (ROS) and thereby impair host defense to enteric pathogens, including Campylobacter spp. Cbowel diseases (IBD) Crohn’s disease and ulcerative colitis (UC) are caused by ...
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ژورنال
عنوان ژورنال: Inflammatory Bowel Diseases
سال: 2015
ISSN: 1078-0998
DOI: 10.1097/mib.0000000000000329